2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2624
    st-Ht31 188425-80-1 98%
    st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage.
    st-Ht31
  • HY-P2633
    Dentonin 400090-20-2 98.63%
    Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature osteoblasts. Dentonin can be used for the research of phosphate homeostasis and bone metabolism.
    Dentonin
  • HY-P2634
    Acetyl pentapeptide-1 97530-32-0 98%
    Acetyl pentapeptide-1 is a pentapeptide. Acetyl pentapeptide-1 combined with other oligopeptides can enhance the skin barrier function.
    Acetyl pentapeptide-1
  • HY-P2678
    CCK (26-31) non-sulfated 89911-64-8 98%
    CCK (26-31) (non-sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety. CCK (26-31) is also less active in non-sulfated than in sulfated form.
    CCK (26-31) non-sulfated
  • HY-P2682
    MMP-8/MMP-26 Fluorogenic substrate 135662-05-4 98%
    MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis.
    MMP-8/MMP-26 Fluorogenic substrate
  • HY-P2703
    Peptide YY (pig) 81858-94-8 98%
    Peptide YY (pig) is a 36 amino acid gastrointestinal peptide, can be isolated from porcine duodenum. Peptide YY (pig) decreases appetite and food-intake by activation of the Y2 receptor. Peptide YY (pig) is present mainly in pancreatic endocrine cells with effect on both intestinal motility and the cardiovascular system.
    Peptide YY (pig)
  • HY-P2723
    Dextran sucrase 9032-14-8 98%
    Dextran sucrase is an extracellular glucosyltransferase (GTF) that catalyses the transfer of D-glucopyranosyl residues from sucrose to dextran.
    Dextran sucrase
  • HY-P2769
    Agarase 37288-57-6
    Agarase is a glycosidase that catalyzes the hydrolysis of agar into oligosaccharides.
    Agarase
  • HY-P2771
    Pectinesterase 9025-98-3
    Pectinesterase is a ubiquitous cell wall-associated enzyme. Pectinesterase is an enzyme responsible for the demethylation of galacturonyl residues in high-molecular-weight pectin.
    Pectinesterase
  • HY-P2792
    Beauveriolide III 221111-70-2 99.9%
    Beauveriolide III is an inhibitor of lipid droplet formation in mouse macrophages.
    Beauveriolide III
  • HY-P2819
    Phosphofructokinase 1 9001-80-3 98%
    Phosphofructokinase 1 (PFK1) is a major regulatory enzyme targeting glycolytic pathway. Phosphofructokinase 1 catalyzes the phosphorylation of fructose-6-phosphate (F6P) to fructose-1,6-bisphosphate (F1,6BP) to regulate glycolytic flux. Phosphofructokinase 1 is promising for research of cancer metabolic reprogramming (e.g., hypoxia adaptation, oxidative stress resistance) and metabolic syndromes.
    Phosphofructokinase 1
  • HY-P2837
    Oxaloacetate decarboxylase 9024-98-0
    Oxaloacetate decarboxylase catalyzes the irreversible decarboxylation of oxaloacetate to pyruvate and COIC2. Oxaloacetate decarboxylase is a member of the sodium ion transport decarboxylase (NaT-DC) enzyme family. Oxaloacetate decarboxylase converts the chemical energy of the decarboxylation reaction into an electrochemical gradient of Na+ ions across the membrane.
    Oxaloacetate decarboxylase
  • HY-P2855
    Phenylpyruvate tautomerase 9023-54-5 98%
    Phenylpyruvate tautomerase catalyzes the interconversion of the enol and keto isomers of phenylpyruvate and (p-hydroxyphenyl)pyruvate.
    Phenylpyruvate tautomerase
  • HY-P2856
    Phosphatidylinositol phosphodiesterase 37288-19-0
    Phosphatidylinositol phosphodiesterase hydrolyzes phosphatidylinositol to diacylglycerols and a mixture of myoinositol 1- and 1, 2-cyclic phosphates.
    Phosphatidylinositol phosphodiesterase
  • HY-P2864
    Rhodanese 9026-04-4 98%
    Rhodanese is the detoxification enzyme in sulfur metabolism for cyanide detoxification. Rhodanese is a mitochondrial protein.
    Rhodanese
  • HY-P2865
    Guanylate kinase 9026-59-9 98%
    Guanylate kinase is a central enzyme in the guanine salvage pathway. Guanylate kinase catalyses the reversible Mg2+-dependent transfer of the terminal phosphoryl group from ATP to GMP, or dGMP.
    Guanylate kinase
  • HY-P2872
    Thioglucosidase 9025-38-1
    Thioglucosidase is a S-glycosidic bond hydrolase. Thioglucosidase is promising for research of plant defense metabolites (e.g., glucosinolates).
    Thioglucosidase
  • HY-P2892
    Fumarase 9032-88-6 98%
    Fumarase catalyses the conversion of l-malic acid to fumaric acid. Fumarase participates in the tricarboxylic acid cycle in mitochondria. Fumarase participates in the cellular response to DNA double strand breaks.
    Fumarase
  • HY-P2951
    Phenylalanine ammonia-lyase 9024-28-6
    Phenylalanine ammonia-lyase is a non-mammalian enzyme converting phenylalanine into trans-cinnamic acid and ammonia. Phenylalanine ammonia-lyase can be used in the research of phenylketonuria.
    Phenylalanine ammonia-lyase
  • HY-P2966
    Protein-arginine deiminase 75536-80-0 98%
    Protein-arginine deiminase is a unique family of enzymes that catalyzes the hydrolysis of peptidyl-arginine to form peptidyl-citrulline.
    Protein-arginine deiminase
Cat. No. Product Name / Synonyms Application Reactivity